Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral m...

• Author(s): Guiyedi, V. ; Chanseaud, Y. ; Fesel, C. ; Snounou, G. ; Rousselle, J.C. ; Lim, P. ; Koko, J. ; Namane, A. ; Cazenave, P.A. ; Kombila, M. ; Pied, S.
• Date: 2007
• Persistent ID: http://hdl.handle.net/10400.7/214
• Origin: ARCA - Access to Research and Communication Annals
• Subject(s): Immunoglobulin G/immunology; Malaria, Cerebral/immunology; Malaria, Falciparum/immunology; Spectrin/immunology
• Document Type: Article
• Language: English

Description

Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children